He was born on May 1, 1872 in a town Kalupur in district Jaunpur. He graduated from MAO College and started practice in 1903 at Lucnkow. In 1920 he became Additional Commissioner and worked as a Judge in Chief Court and Oudh in 1925. In 1930, was appointed Chief Judge. After quilting in 1934, begun legal practice in Allahabad. He was knighted in 1932.

He was one of the founder workers of the All-India Muslim League when it was founded in 1906. he worked as first President Secretary General on the occeasion of the League session held at Delhi in 1918. He was elected Secretary of the League in he in the League’s annual session held at Lucknow in 1913. He occompanied Maulana Muhamamd Ali Jauhar to London when he persuaded the Quaid-e-Azam to join All-India Muslim League. Syed Wazir Hasan was nominated member of the joint committee of the League and the Indian National Congress set up for constitutional reforms. Between 1916-1919, he remained member of the UP Assembly. In 1936, he presided over the 24th League annual session held at Bombay. In 1937, he was ousted from the league because of some differences but did not opt to join the Hindu Congress and, instead withdraw himself from active politics. He remained member of the syndicates of Aligarh, Allahabad and Lucknow universities. He died in August 1947.